" Compared to other supplements, there is a good level of scientific evidence supporting the potential benefit of CoQ10 for male fertility. This antioxidant might improve semen parameters, including sperm quantity and quality. "
– Dr. Ramy Abou Ghayda, urologist, researcher, Legacy Chief Medical Officer
Understanding sperm quality
Research shows CoQ10 may boost sperm concentration, motility, and morphology when taken as part of a healthy lifestyle.
Sperm concentration is the number of sperm (sperm count) per mL of semen.
Sperm motility refers to the ability of the sperm to move or “swim".
Sperm morphology means the sperm’s size, structure, and shape.
CoQ10 is an antioxidant. Antioxidants protect the body’s cells against free radicals and oxidative stress.
Free radicals are unstable molecules produced as natural byproducts of daily life, such as toxin exposure, illness, and poor lifestyle.
If left unchecked, free radicals can cause damage to our cells. This damage is known as “oxidative stress,” and can be detrimental to the health of your sperm.
Antioxidants such as CoQ10 neutralize free radicals and prevent damage. That’s why CoQ10 may support the production of healthy sperm.
Additionally, there is evidence that CoQ10 supplementation can enhance your heart health, brain health, and overall wellness.
Balercia et al, 2009: Patients with reduced sperm motility were treated with CoQ10, 200mg per day for 6 months. Supplementation was associated with increased antioxidant levels in semen and improved sperm motility (by about 19%).
Nadjarzadeh et al, 2013: Men with low sperm count and poor motility/morphology received 200mg of CoQ10 daily for 3 months. Compared to the placebo group, the supplement group had a significant improvement in sperm morphology.
Safarinejad et al, 2012: Men with unexplained infertility were treated with 200mg of CoQ10 daily for 26 weeks. Supplementation was associated with a statistically significant improvement in sperm concentration, motility, and morphology.
Safarinejad, 2009: Men with low sperm count and poor motility/morphology received 300mg of CoQ10 daily for 26 weeks. A positive correlation was found between CoQ10 treatment and sperm count, motility, and morphology.
Thakur et al, 2015: Sixty men were treated with 150mg of CoQ10 daily. After 6 months of supplementation, sperm count was increased by 53%, along with significant improvement in sperm motility.
Vishvkarma et al, 2020: Pooling data from three clinical trials on CoQ10, researchers found that supplementation had a profound effect on sperm motility, and that the ideal treatment period was 3–6 months.
Start with baseline sperm testing
Not everyone will need CoQ10. Before you try a supplement to improve your fertility, you should understand where your sperm health is right now.
We recommend completing a semen analysis as the first step.
Who should take CoQ10?
CoQ10 may help enhance sperm health. This is especially important for men who are trying to conceive or men who are considering sperm freezing.
How much CoQ10 should I take per day?
The recommended dosage is 2–3 softgels, or 200–300mg of CoQ10, per day. Do not exceed the recommended dosage.
When should I stop taking CoQ10?
Sperm production takes 2–3 months, so it may take 3–6 months to see the positive effect of CoQ10 supplementation. We recommend supplementing with CoQ10 for up to 6 months or as directed by your doctor.
Is CoQ10 safe? Will I have any side effects while taking CoQ10?
When taken at the recommended dosage, side effects are rare and mild. While CoQ10 is safe overall, we recommend talking to your doctor before starting any new regimen.
How do I improve my fertility overall?
Supplements aren’t a silver bullet—they’re just one small part of sperm health improvement. Lifestyle changes such as a healthy diet, moderate exercise, and enough sleep are important for your fertility, as is quitting smoking and reducing alcohol consumption. See your personalized recommendations (part of your Legacy semen analysis report) or our Guide to Sperm Improvement for more information.
Can I use my FSA or HSA to pay for CoQ10 supplements?
If you have a flexible spending account (FSA), health savings account (HSA), or health reimbursement arrangement (HRA), Legacy's CoQ10 supplements may be eligible for coverage if it's recommended by your healthcare provider. We recommend consulting your doctor and checking with your benefits coordinator to understand any specific requirements for reimbursement, such as a letter of medical necessity, or limits on usage or protocols. If your purchase is eligible, you can use your HSA/FSA card or submit your itemized receipt — sent to your inbox after purchasing — for reimbursement.
Legacy is for people with sperm who want to learn more about their personal health. Legacy tests are exclusively intended to be used for wellness purposes. While the tests we offer provide detailed results, they cannot provide a diagnosis and are not intended to replace the advice of your physician. Legacy cannot provide you with medical advice or diagnose you with any disease or condition. Our tests are available anywhere in the United States. We currently are unable to provide tests for international clients.